Autocatalytic base editing for RNA-responsive translational control
Autocatalytic base editing for RNA-responsive translational control
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Genetic circuits that control transgene expression in response to pre-defined transcriptional getpureroutine.com cues would enable the development of smart therapeutics.Here the authors engineer programmable RNA sensors, DART VADARs, in which ADARs autocatalytically convert target hybridization into a translational output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a 2014 dodge ram 1500 fender flares small genetic footprint.
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